IMR Press / CEOG / Volume 44 / Issue 6 / DOI: 10.12891/ceog3565.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
A case of a pregnant patient with antiphospholipid antibody syndrome, deep vein thrombosis, and heparin-induced thrombocytopenia who suffered an intrauterine fetal death
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1 Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan
2 Department of Obstetrics and Gynecology, Keiai Hospital, Obihiro, Japan
Clin. Exp. Obstet. Gynecol. 2017, 44(6), 939–940;
Published: 10 December 2017

Antiphospholipid antibody syndrome (APS) is an autoimmune disease caused by the persistence of antiphospholipid antibodies. Moreover, there is a significantly increased risk of pregnancy complications in women with APS. The treatment is antithrombotic therapy. However, heparin-induced thrombocytopenia (HIT) is known as a severe complication of heparin utilization. HIT is an autoimmune disease caused by anti-heparin antibodies. Nevertheless, patients with APS frequently receive heparin as treatment for thrombotic events. The authors report a case of a Japanese woman with Sjögren's syndrome (SjS) and deep vein thrombosis who became pregnant following assisted reproduction technology. However, she suffered an intrauterine fetal death associated with HIT.
Antiphospholipid antibody syndrome
Sjögren’s syndrome
Heparin-induced thrombocytopenia
Intrauterine fetal death
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