IMR Press / CEOG / Volume 44 / Issue 4 / DOI: 10.12891/ceog3597.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
First trimester maternal serum marker in intrahepatic cholestasis of pregnancy
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1 Department of Gynecology and Obstetrics, Sisli Etfal Traning and Research Hospital, Istanbul, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(4), 595–598;
Published: 10 August 2017
Purpose of investigation: The authors investigated the difference between the first-trimester maternal serum markers of intrahepatic cholestasis of pregnancy (ICP) cases and uneventful pregnancies, which might be useful in disease prediction. Materials and Methods: Twenty patients who had ICP and 40 pregnant women as control group were enrolled and the first-trimester maternal serum markers, maternal and fetal outcomes were compared between two groups. First trimester maternal serum markers: pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) are the essential components of aneuploidy screening and prediction of adverse obstetric outcome. Results: Serum PAPP-A and free β-hCG levels were significantly higher in the ICP group. The mean serum PAPP-A was significantly higher in the ICP than control groups (2.4 ± 0.9 MoM vs. 1.2 ± 0.3 MoM: p < 0.001, respectively) and the mean of serum free β-hCG was significantly higher in the ICP than control groups (1.8 ± 1.5 MoM vs. 1.2 ± 0.6 MoM; p = 0.036, respectively). Gestational week at birth and the birth weights were lower in the ICP group (p < 0.001 and p = 0.005, respectively). Conclusion: The first-trimester maternal serum markers were elevated in case of ICP and this might be useful in disease prediction.
Bile acids
Free β-hCG
Intrahepatic cholestasis of pregnancy
Pregnancy associated plasma protein A
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