IMR Press / CEOG / Volume 44 / Issue 4 / DOI: 10.12891/ceog3369.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Clinical screening method and risk factors’ analysis of congenital cardiovascular defects: a case control study from a Chinese local region
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1 Department of Cardiac Surgery, Maternal and Child Health Hospital of Taian, Taian, China
2 The Children's Hospital of Fudan University, Shanghai, China
Clin. Exp. Obstet. Gynecol. 2017, 44(4), 515–520;
Published: 10 August 2017
Aim: To explore the effective clinical screening method and risk factors of congenital heart disease (CHD) in neonates. Materials and Methods: The authors screened neonatal congenital heart diseases using eight clinical screening indexes and analyzed to acquire the simplest and most effective screening method. They also conducted a hospital-based 1:1 matched case (total 64 cases) – control study to analyze a series of underlying risk factors. Result: The eight clinical indexes are reliable screening means. The main risk factors influencing the incidence of CHD in the present samples were abnormal reproductive history (p = 0.008), negative stimulus (p = 0.075), upper respiratory infection (p = 0.06), diabetes mellitus (p = 0.058), high blood pressure (p = 0.041), husband's cigarette smoking (p = 0.001), and gravidity (p = 0.000). Conclusion: The eight clinical indexes were reliable means to screen CHD in neonates. Eliminating abortion or other abnormal reproduction, augmenting maternal mental healthcare, preventing upper respiratory tract infections, limiting medication during early pregnancy including antihypertensive agent, controlling blood glucose levels, and abstaining from cigarette may lower the occurrence of CHD.
Congenital heart disease
Risk factors
Case control study
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