IMR Press / CEOG / Volume 44 / Issue 3 / DOI: 10.12891/ceog3627.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
The importance of some angiogenic markers in spontaneous abortion
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1 Ataturk University, Faculty of Medicine, Department of Medical Biochemistry, Erzurum, Turkey
2 Nenehatun Obstetrics Hospital, Erzurum, Turkey
3 Regional Training and Research Hospital, Department of Biochemistry, Erzurum, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(3), 444–447; https://doi.org/10.12891/ceog3627.2017
Published: 10 June 2017
Abstract
Aim: In this study, the authors aimed to determine the serum levels of vascular endothelial growth factor (VEGF), angiopoietin-1 (ang- 1) and angiopoietin-2 (ang-2) factors as indicators of placental angiogenesis and vasculogenesis in abortion cases. Materials and Methods: This study was conducted in 40 women who were pregnant for 7-20 weeks and diagnosed with an incipient abortion and 40 pregnant healthy women with similar ages, gestational weeks, and body mass index (BMI) values. Serum VEGF, ang-1, and ang-2 levels were measured with ELISA methods. Results: The authors found that the serum VEGF levels were higher and ang-1 levels were significantly lower in pregnant women whose pregnancies failed with abortion, compared to control group. There was no significant difference in terms of ang-2 levels between groups. Conclusion: A strong relationship was found between VEGF and ang-1 early pregnancy loss, and significant changes of these factors may also be associated with the physiopathology of abortion incipience. Evaluating these factors may be benefical for prediction and designing of treatment modalities on spontaneous abortion.
Keywords
Abortus
VEGF
Angiopoietin-1 (Ang-1)
Angiopoietin-2 (Ang-2)
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