IMR Press / CEOG / Volume 44 / Issue 3 / DOI: 10.12891/ceog3472.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
May supplementation of coenzyme Q10 help prevent development of hydatidiform mole?
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1 Department of Obstetrics and Gynaecology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey
2 Faculty of Health Sciences, Giresun University Piraziz, Giresun, Turkey
3 Department of Biochemistry, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey
4 Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(3), 398–402; https://doi.org/10.12891/ceog3472.2017
Published: 10 June 2017
Abstract
Objective: The pathological mechanisms of gestational trophoblastic disease have not yet been clearly determined. It is thought that oxidative damage contributes to the process. The aim of this study was to determine the levels of coenzyme Q10 (CoQ10), DNA damage, and lipid peroxidation in patients with hydatidiform mole. Materials and Methods: The authors studied the levels of CoQ10, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA) by high-performance liquid chromatography (HPLC), and the activity of glutathione peroxidase (GPX) by spectrophotometric method in blood obtained from patients with a complete hydatidiform mole (n=29), healthy pregnant women (n=29), and healthy non-pregnant women (n=29). Results: The 8-OHdG/dG ratio (2.8148 ± 0.81592) and MDA (10.8341 ± 4.64875 μmol) were significantly higher in patients with complete hydatidiform mole, while the ubiquinol- 10/ubiquinone-10 ratio (0.2107 ± 0.15675) and GPX activity (43.4606 ± 18.31694 mU/ml) were lower (p < 0.001). Conclusion: The authors suggest that both mitochondrial oxidative and oxidative DNA damage play important roles in the pathogenesis of complete hydatidiform mole. Therefore supplementation of CoQ10 prevents recurrent gestational trophoblastic disease.
Keywords
Coenzyme Q10
Ubiquinol
DNA damage
Oxidative stress
Antioxidants
Hydatidiform mole
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