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Original Research
Assessment of 8-hydroxydeoxyguanosine levels in patients with preeclampsia: a prospective study
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1
Gaziantep University, School of Medicine, Dpt. of Obstetrics and Gynecology, Gaziantep, Turkey
2
Medipol University, School of Medicine, Dpt. of Obstetrics and Gynecology, Istanbul, Turkey
3
Gaziantep University, School of Medicine, Dpt. of Biochemistry, Gaziantep, Turkey
4
Gaziantep Cengiz Gokcek Maternity Hospital, Dpt. of Obstetrics and Gynecology/Gaziantep, Turkey
Clin. Exp. Obstet. Gynecol. 2017, 44(2), 226–229;
https://doi.org/10.12891/ceog3474.2017
Published: 10 April 2017
Abstract
Purpose of investigation: To determine the levels of 8-hydroxydeoxyguanosine (8-OHdG) in preeclampsia (PE) using (enzymelinked immunosorbent assay (ELISA) method. Materials and Methods: Twenty-two pregnant women with severe PE, 18 pregnant women with mild PE, and 40 healthy pregnant women, all between 25 and 41 weeks of gestation, were enrolled in this prospective controlled study. 8-OHdG levels in maternal serum were measured using ELISA method. Results: The authors observed no statistically significant difference in 8-OHdG levels between the mild-severe PE and control groups (p = 0.208). Conclusion: The present results do not support the concept that 8-OHdG has a role in the etiopathogenesis of PE.
Keywords
Oxidative stress
Preeclampsia
8-hydroxydeoxyguanosine