IMR Press / CEOG / Volume 44 / Issue 1 / DOI: 10.12891/ceog3148.2017

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Experimental Research
The effect of leflunomide on the transplanted endometriosis lesions in SD rats
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1 The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2 Women and Infants Hospital of Zhengzhou, Zhengzhou, China
Clin. Exp. Obstet. Gynecol. 2017, 44(1), 129–132;
Published: 10 February 2017

Objective: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and transforming growth factor (TGF) -β1gray level in SD rats. Materials and Methods: EMS was surgically induced in rats by autologous transplantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml·kg-1·d-1 saline for three weeks, and group C: rats irrigated by 35 mg·kg-1·d-1 LEF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. Results: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. Conclusion: LEF could be a new therapeutic drug for EMS.
Ectopic endometriosis model in rats
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