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Experimental Research
The effect of leflunomide on the transplanted endometriosis lesions in SD rats
J.J. Yang1, 2, Y. Gao2, Y.H. Wang2, C.H. Wang2, L.D. Wang1, *, B.B. Tao2, H.F. Guo2, S.G. Ding2, A.H. Wu2, G.R. Zhai2, X.M. Feng2
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1
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2
Women and Infants Hospital of Zhengzhou, Zhengzhou, China
Clin. Exp. Obstet. Gynecol. 2017, 44(1), 129–132;
https://doi.org/10.12891/ceog3148.2017
Published: 10 February 2017
Abstract
Objective: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and transforming growth factor (TGF) -β1gray level in SD rats. Materials and Methods: EMS was surgically induced in rats by autologous transplantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml·kg-1·d-1 saline for three weeks, and group C: rats irrigated by 35 mg·kg-1·d-1 LEF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. Results: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. Conclusion: LEF could be a new therapeutic drug for EMS.
Keywords
Ectopic endometriosis model in rats
Endometriosis
Leflunomide
TGF-β1