IMR Press / CEOG / Volume 43 / Issue 6 / DOI: 10.12891/ceog3390.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Immunohistochemical expression of hormonal receptors, collagen, elastin, and proteoglycans in genuine urinary incontinence
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1 Aretaieion Hospital, Athens
2 Pathology Department, Aretaieion Hospital, Athens
3 Mitera Maternity Hospital, Athens
4 Pathology Laboratory, Aretaieion Hospital, Athens
5 Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens (Greece)
Clin. Exp. Obstet. Gynecol. 2016, 43(6), 849–852; https://doi.org/10.12891/ceog3390.2016
Published: 10 December 2016
Abstract

Purpose: To study the expression of hormonal receptors, collagen, elastin, proteoglycans, and VIP in the vaginal wall of women with stress urinary incontinence (SUI). Materials and Methods: Fifty-eight specimens of the anterior vaginal wall (28 women with SUI) were processed by Ventana immunostaining method. Results: Both groups were compatible for age, BMI, and obstetric history. Positive ER-α and ER-β immunoreaction was observed in 46.4% and 3.6% of SUI (43.3% and 33.3 % of controls) (p < 0.05), respectively, and PR immunoreaction in 39.3% of SUI (46.7% of controls). Collagen I and III immunoreaction was observed in 28,6% and 21.4 % of SUI (30.% and 36.7% of controls), respectively, and elastin, decorin, and fibromodulin immunoreaction in 10.7 %, 10.7%, and 10.7% of SUI (50%, 33.3%, 33,.3% of controls) (p < 0.05), respectively. VIP immunoreaction was observed in 7.1% of SUI (36.7% of controls). Conclusion: Immunoexpression of ER-β, elastin, decorin, fibromodulin, and VIP was significantly lower in SUI than controls, showing that the ER-β dependent re-modeling of the extracellular matrix of vaginal tissues is the main mechanism of SUI.
Keywords
Incontinence
Hormones
Collagen
Elastin
Proteoglycans
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