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Original Research
The predictor markers of ovarian response in poor responders under 40 years of age
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1
Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, Kocaeli
2
Haydarpaşa Numune Teaching Hospital, Obstetrics and Gynecology Clinic, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2016, 43(5), 650–653;
https://doi.org/10.12891/ceog2137.2016
Published: 10 October 2016
Abstract
Objective: To explore the ovarian reserve markers in predicting ovarian response and pregnancy rates in poor responder patients undergoing in vitro fertilization (IVF). Material and Methods: A total of 140 women < 40 years with poor ovarian response (POR), who underwent IVF were included in the study. The clinical findings compared with normal responder controls (n= 250). Regression analysis was used to search the correlation between the number of the total oocyte count retrieved and independent variables as age, FSH, LH, AMH, AFC, and E2 on the hCG day. Results: AUC ROC curve were AMH 0.804, AFC 0.701, E2 on hCG day 0.786, FSH 0.705, LH 0.527, and E2 0.479, age 0.707, respectively. E2 levels on hCG day and AMH levels were independent markers of POR. None of the factors were predictor of pregnancy rate. Conclusion: The serum E2 levels on the hCG day and AMH levels predict ovarian response, but not pregnancy rates.
Keywords
In vitro fertilization
Anti-Müllerian hormone
Poor ovarian response
Cycle cancellation
Ovarian reserve
Pregnancy rate