IMR Press / CEOG / Volume 43 / Issue 4 / DOI: 10.12891/ceog3076.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Serum level and placental expression of resistin in pregnancies complicated by preeclampsia: relationship with disease severity
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1 Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya
2 Department of Pathology, Antalya Training and Research Hospital, Antalya
3 Department of Biochemistry, Antalya Training and Research Hospital, Antalya
4 Department of Medical Informatics, School of Medicine, Akdeniz University, Antalya (Turkey)
Clin. Exp. Obstet. Gynecol. 2016, 43(4), 516–521; https://doi.org/10.12891/ceog3076.2016
Published: 10 August 2016
Abstract

The authors aimed to compare the maternal serum level and placental expression of resistin in pregnancies complicated by preeclampsia and clarify their relationship with disease severity. This cross-sectional study included 50 healthy pregnant women, 50 women with mild preeclampsia, and 48 women with severe preeclampsia. Serum resistin levels were measured by enzyme immunoassay and placental resistin expression was determined by immunohistochemistry. Resistin levels were significantly higher in women with mild and severe preeclampsia than in the healthy controls (p = 0.012 and p < 0.001, respectively). Placental resistin expression was significantly higher in women with severe preeclampsia compared to women with mild preeclampsia (p = 0.003) and healthy controls (p < 0.001). Serum resistin levels were positively correlated with gestational age and umbilical and uterine artery Doppler indices, as well as systolic and diastolic blood pressure, but negatively correlated with birth weight (p < 0.05). On the other hand, placental resistin expression was positively correlated with systolic blood pressure and uterine artery indices, but negatively correlated with birth weight (p < 0.05). In conclusion, increased circulating levels and placental expression of resistin in pregnancies complicated by preeclampsia were correlated with disease severity.
Keywords
Immunohistochemistry
Pregnancy
Preeclampsia
Resistin
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