IMR Press / CEOG / Volume 43 / Issue 4 / DOI: 10.12891/ceog3028.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Effect of cervical conization on pregnancy outcome of in-vitro fertilization/intracytoplasmic sperm injection treatment: a retrospective cohort study
Lingling Ding1,2,3Miao Li1,2,3Lei Yan1,2,3Rong Tang1,2,3Zi-Jiang Chen1,2,3,*
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1 Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University
1 Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan
2 National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan
3 The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan (China)
Clin. Exp. Obstet. Gynecol. 2016, 43(4), 546–549;
Published: 10 August 2016

Aims: To investigate the effect of cervical conization on the outcome of in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment. Materials and Methods: The authors performed a retrospective, database-searched cohort study based on patients undergoing controlled ovarian hyperstimulation and IVF/ICSI between 2009 and 2013 in the present hospital. Cervical intraepithelial neoplasia (CIN) or cervical cancer was carefully confirmed by transvaginal ultrasound, hysteroscopy, and biopsy. High-quality case-control study with strict inclusion criteria was conducted. The authors analyzed basic characters and main IVF/ICSI outcomes between both groups. Results: The authors included 48 patients with a history of cervical conization who underwent IVF/ICSI and control group without cervical conization. No significant differences were found in IVF/ICSI outcomes between both groups. No obvious evidence was found indicating that cervical stenosis could impact IVF operation. Conclusions: The present results suggest that cervical conization does not affect IVF/ICSI outcomes. Patients can receive cervical conization before undertaking assisted reproductive technology.
Cervical conization
In vitro fertilization
Cohort study
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