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Cite this article
Failure to increase the thickness of thin endometria with intrauterine infusion of granulocyte colony stimulating factor (G-CSF)
1 Cooper Medical School of Rowen University Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ
2 Cooper Institute For Reproductive Hormonal Disorders, P.C. Marlton, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2016, 43(3), 332–333; https://doi.org/10.12891/ceog3232.2016
Published: 10 June 2016
Purpose: To corroborate or refute a previous study suggesting that intrauterine infusion of granulocyte colony stimulating factor (GCSF) could significantly improve endometrial thickness into more fertile levels when the endometrial thickness was ≤ five mm. Materials and Methods: Three women whose endometrial thickness never exceeded five mm on the in vitro fertilization-embryo transfer(IVF-ET) cycle or subsequent attempted frozen ETs using graduated estradiol had intrauterine infusion of G-CSF to the estradiol regimen. Results: Not one of the three women improved the endometrial thickness beyond five mm and none conceived on the G-CSF cycle. One woman had a subsequent pregnancy following a frozen ET with only a four-mm thickness with no infusion of G-CSF. Conclusions: These data do not confirm the efficacy of intrauterine infusion of G-CSF for poor endometrial thickness. Perhaps only certain cases will respond. A larger series could take time to accumulate since other studies have shown that only 0.3% of women with ≤ five mm endometrial thickness in the late proliferative phase during an IVF-ET cycle will not improve the endometrial thickness > five mm using graduated estradiol protocols.
Granulocyte-colony stimulating factor (G-CSF)
Graduated estradiol therapy