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Original Research
Evaluation of sialic acid levels in patients with hydatidiform mole: a preliminary study
H. Ç. Özcan Özcan1,*, E. Öztürk Öztürk2, S. Sucu3, M. G. Uğur Uğur1, I. Kutlar1, Ö. Balat1, B. Erbağci Erbağci4
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1
Gaziantep University, School of Medicine, Department of Obstetrics and Gynecology, Gaziantep
2
Medipol University, School of Medicine, Department of Obstetrics and Gynecology, Istanbul
3
Gaziantep Cengiz Gokcek Maternity Hospital, Department of Obstetrics and Gynecology, Gaziantep
4
Gaziantep University, School of Medicine, Department of Biochemistry, Gaziantep (Turkey)
Clin. Exp. Obstet. Gynecol. 2016, 43(3), 414–416;
https://doi.org/10.12891/ceog2156.2016
Published: 10 June 2016
Abstract
Purpose of investigation: This study aims to investigate whether hydatidiform mole (HM) disease with malignant potential is significantly associated with increased sialic acid (SA) levels. Materials and Methods: A total of 114 women were enrolled in this study. Patients were divided into three groups including HM (Group 1, n=34), control group including non-pregnant healthy patients (Group 2, n=42), and another control group including healthy pregnant patients within 12 weeks of gestation (Group 3, n=38). Serum-free SA levels were measured. Results: There was a statistically significant difference in serum-free SA levels among the groups (p ≤ 0.001). Patients with HM had significantly higher levels compared to the control groups. Conclusion: The present study results showed that there was a significant correlation between HM and serum SA level.
Keywords
Hydatidiform mole
Sialic acid
Pregnancy