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Cite this article
The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis
1 Recep Tayyip Erdogan University, Faculty of Medicine, Department of Pathology, Rize
2 Recep Tayyip Erdogan University, Faculty of Medicine, Department of Obstetrics and Gynecology, Rize
3 Marmara University, Faculty of Medicine, Department of Pathology, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2016, 43(3), 463–466; https://doi.org/10.12891/ceog2150.2016
Published: 10 June 2016
Objective: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. Materials and Methods: Nectin-4 expression was investigated in ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometriumof endometriosis (n=20), and in a control group (having no endometriosis) (n=20) by immunohistochemical method. Results: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). Conclusion: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.