IMR Press / CEOG / Volume 43 / Issue 3 / DOI: 10.12891/ceog2103.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Maternal hyperthyroidism after intrauterine insemination due to hypertrophic action of human chorionic gonadotropin: a case report
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1 2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Division of Assisted Reproduction, Athens (Greece)
Clin. Exp. Obstet. Gynecol. 2016, 43(3), 446–447;
Published: 10 June 2016

Purpose of investigation: To report a rare case of maternal hyperthyroidism after intrauterine insemination due to hypertrophic action of hCG. Materials and Methods: A 36-year-old woman after successful intrauterine insemination and triplet pregnancy, developed hyperthyroidism with resistance to medical treatment. Results: All signs of hyperthyroidism resolved and the results of thyroid function tests returned to normal without any medication after embryo meiosis. Conclusions: De novo maternal hyperthyroidism may develop during pregnancy as a result of pathological stimulation of the thyroid gland from the high levels of hCG hormone that can be seen in multiple pregnancies. The risk of hyperthyroidism is related to the number of fetuses. Reversibility of symptomatology can be seen after fetal reduction of multiple pregnancies.
Thyrotropic action of hCG
Multiple pregnancy
Thyroidal hyperstimulation
Embryo meiosis
Maternal hyperthyroidism
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