IMR Press / CEOG / Volume 43 / Issue 2 / DOI: 10.12891/ceog2118.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Efficiency of GnRH analogues in treating large functional ovarian cysts
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1 Rea Hospital Breast Dept, Technological Educational Institute of Athens, Athens
2 Department of Obstetrics & Gynecology, Technological Educational Institute of Athens, Athens
3 University of Athens, Midwifery Department, Technological Educational Institute of Athens, Athens
4 University of Athens, Clinical Endocrinology, Aretaieio Hospital, Athens (Greece)
Clin. Exp. Obstet. Gynecol. 2016, 43(2), 230–232;
Published: 10 April 2016

Aim: The aim of this study was to determine the potential therapeutic benefit of a single administration of a GnRH analogue in premenopausal women presenting large functional ovarian cysts (FOCs) (diameter > five cm). Materials and Methods: Fifty-one patients (median age 37.4 years) diagnosed with ovarian cysts, presumed benign based on transvaginal and/or transabdominal ultrasound, were divided in three study groups. Patients of group A received no medication whereas patients of groups B and C were treated with a single administration of a GnRH analogue and combined oral contraceptives, respectively. Patients were re-examined after a three-month period. Three of the 51 patients were lost in follow-up or stopped the treatment. Results: Complete resolution of the ovarian cysts was observed in eight (50%), 14 (70%), and eight (67%) patients of groups A, B, and C, respectively. No side effects were observed in either of the three groups. The positive therapeutic effect in group B did not reach statistical significance compared with the two other groups (p > 0.05). Conclusion: A new option of treating large FOCS through a single-dose of a GnRH analogue is proposed and should be carefully considered. Further research is needed in order to evaluate GnRH analogues as an alternative treatment.
Functional ovarian cysts
GnRH analogues
Benign ovarian tumors
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