IMR Press / CEOG / Volume 43 / Issue 2 / DOI: 10.12891/ceog2089.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Prenatal diagnosis of Binder’s syndrome: report of two cases
Show Less
1 Prenatal Diagnosis Department, Obstetrics and Gynecology, Hospital Universitari Parc Taulí, Sabadell, Barcelona
2 Director of the Prenatal Diagnosis Department, Obstetrics and Ginecology, Hospital Universitari Parc Taulí, Sabadell, Barcelona (Spain)
Clin. Exp. Obstet. Gynecol. 2016, 43(2), 279–283; https://doi.org/10.12891/ceog2089.2016
Published: 10 April 2016
Abstract

Objective: Binder syndrome is a rare congenital malformation presenting an abnormal maxilla′s development associated to other characteristical facial features, like absence or decreased nasal bridge, short nasal columella, convex upper lip with associated dental Angle Class III malocclusion, atrophy of the nasal mucosa, and absence of the frontal sinus. Mental retardation and other clinical signs may also be present. Two cases of Binder syndrome were diagnosed at 22 weeks of gestation during the second trimester ultrasound (2D). Cases Report: The first feature detected, in both cases, was a flattened fetal nose in the mid-sagittal plane. Further controls objectivated absence of the naso-frontal angle and a mild hypertelorism. In both cases the parents were informed of the findings and the impossibility of excluding other associated features diagnosed after birth. Once the differential diagnosis was performed, one of the couples decided to terminate the pregnancy. The findings postmortem confirmed the diagnosis. In the second case, the newborn presented the phenotype previously detected, however, a normal psychomotor development was eventually evidenced. Conclusion: The Binder syndrome is an uncommon clinical entity with a recognizable congenital condition characterized by a retruded midface and an extremely flat nose. The exact birth prevalence remains unknown. It is important to understand that Binder’s syndrome has a variable prognosis, depending on the other associated features it presents. When diagnosed, an accurate differential diagnosis has to be performed.
Keywords
Binder syndrome
Maxillo-facial displasia
Prenatal diagnosis
Share
Back to top