IMR Press / CEOG / Volume 43 / Issue 1 / DOI: 10.12891/ceog2039.2016

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
The possible role of serum leptin in preeclampsia
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1 Department of Obstetrics and Gynecology, Medipol University School of Medicine, Istanbul
2 Department of Obstetrics and Gynecology, Uludag University School of Medicine, Bursa (Turkey)
Clin. Exp. Obstet. Gynecol. 2016, 43(1), 98–102; https://doi.org/10.12891/ceog2039.2016
Published: 10 February 2016
Abstract

Background: It is theorized that adipokines play a critical role in the pathophysiology of preeclampsia, particularly with their pro-inflammatory and inflammatory features. Aim: To investigate serum leptin levels in pregnancies complicated with preeclampsia and severe preeclampsia. Materials and Methods: Maternal serum leptin levels were analyzed by solid phase enzyme amplified sensitivity immunoassay (EASIA) method in 23 patients with mild preeclampsia, 29 patients with severe preeclampsia, and 28 healthy pregnant controls. Results: Mean serum leptin levels did not differ statistically between patients with mild preeclampsia, severe preeclampsia, and the controls (10.77 ng/ml, 13.40 ng/ml, and 8.43 ng/ml, respectively). Also, there was no relationship between serum leptin levels and the gestational ages of the participants. Discussion: Serum leptin levels are not associated with preeclampsia. Leptin measurements are not affected with the gestational age. The role of leptin in the pathophysiology of preeclampsia should be evaluated cautiously.
Keywords
Preeclampsia
Severe preeclampsia
Adipokine
Leptin
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