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Original Research
Non-association of MMP-9 -1562C/T polymorphism with preeclampsia risk: evidence from a meta-analysis
C. M. Wang1,*, S. L. Zhang2
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1
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of the Southeast University, Nanjing
2
Department of General Surgery, Zhongda Hospital, Medical College of Southeast University, Nanjing (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(6), 730–735;
https://doi.org/10.12891/ceog2010.2015
Published: 10 December 2015
Abstract
Individual genetic association studies examining the relationship between the MMP-9 -1562C/T polymorphism (rs3918242) and preeclampsia risk have yielded inconsistent results. Objective: This study aims to evaluate the association between the MMP-9 - 1562C/T polymorphism and preeclampsia risk using meta-analysis. Materials and Methods: Relevant studies were identified by searching PubMed database. Data were extracted and statistical analysis was performed using STATA 12.0 software. A total of six publications involving 871 cases and 845 controls were included in this meta-analysis. Results: Combined analysis revealed no association between the MMP-9 -1562C/T polymorphism and preeclampsia risk (allelic model: OR = 1.10, 95% CI 0.86 - 1.41, Pheterogeneity= 0.07; recessive model: OR = 0.38, 95% CI 0.14-1.01, Pheterogeneity= 0.64; dominant model: OR = 1.09, 95% CI 0.70 - 1.69, Pheterogeneity = 0.01; homozygous model: OR = 0.41, 95% CI 0.15 - 1.09, Pheterogeneity = 0.67; heterozygous model: OR = 1.36, 95% CI 0.80 - 2.29, Pheterogeneity = 0.01). Similarly, subgroup analysis by ethnicity showed that MMP-9 -1562C/T polymorphism was not associated with preeclampsia risk in Brazilian (allelic model: OR = 1.37, 95% CI 0.92 - 2.05, Pheterogeneity= 0.61; recessive model: OR = 0.80, 95% CI 0.18 - 3.57, Pheterogeneity= 0.58; dominant model: OR = 1.12, 95%CI 0.60-2.10, Pheterogeneity= 0.03; homozygous model: OR = 0.87, 95%CI 0.19-3.94, Pheterogeneity = 0.62; heterozygous model: OR = 1.55, 95% CI 0.99 - 1.75, Pheterogeneity = 0.32). Conclusion: This meta-analysis indicated that MMP-9 -1562C/T polymorphism was not associated with preeclampsia risk. However, large welldesigned, multi-center epidemiological studies should be carried out in these and other ethnic populations to confirm our findings.
Keywords
MMP-9
Polymorphism
Preeclampsia
Meta-analysis