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Original Research
Middle cerebral artery Doppler in prediction degree of fetal anemia and the best timing for the second intrauterine intravascular transfusion in red cell alloimmune disease
I. Babović Babović1,2,*, S. Plešinac Plešinac1,2, Z. Radojičić Radojičić4, O. Antonović Antonović1,2, R. Sparić Sparić2, D. Plećaš Plećaš1,2, N. Radunović Radunović1,2,3
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1
School of Medicine, University of Belgrade, Belgrade
2
Department of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade
3
Serbian Academy of Sciences and Arts, Belgrade
4
Faculty of Organizational Sciences, University of Belgrade, Institute for Statistics, Belgrade (Serbia)
Clin. Exp. Obstet. Gynecol. 2015, 42(6), 792–796;
https://doi.org/10.12891/ceog2005.2015
Published: 10 December 2015
Abstract
Aim: To determine the role of fetal multiples of the median of middle cerebral artery peak systolic velocity (MoM MCA-PSV), predicts the rate of decline in fetal hematocrit (Hct) for determination of the best timing for the second intrauterine intravascular transfusion (IUIVT) in fetuses with Rh alloimmunisation. Materials and Method: Retrospective study of 59-monofetal alloimmunized pregnancies from 2005 to 2012 that underwent first and second IUIVT were assessed in Department of Gynecology and Obstetrics, Belgrade, Serbia. Result: There was an inverse statistically significant correlation between measurements MCA MoM-1 and fetal Hct-1 before the first IUIVT r = - 0.622; p = 0.001 and MCA-MoM-3 and Hct-3 before the second IUIVT r = - 0.381; p = 0.001, also as the significant correlation between the interval between both procedures (expressed in day) and measurement MCA-MoM-3, before the second IUIVT r = - 0.284; p = 0.029. Conclusion: The measurements MoM-MCA before every IUIVT can be useful for prediction of the best timing for the next IUIVT.
Keywords
Doppler
Hemolytic disease
Hydrops fetalis
Intrauterine intravascular transfusion
RhD antibodies