IMR Press / CEOG / Volume 42 / Issue 6 / DOI: 10.12891/ceog1982.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Cell free fetal DNA in the plasma of pregnant women with preeclampsia
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1 Ankara University School of Medicine, Department of Obstetrics and Gynecology, Ankara
2 Ankara University School of Medicine, Department of Medical Genetics, Ankara (Turkey)
Clin. Exp. Obstet. Gynecol. 2015, 42(6), 787–791; https://doi.org/10.12891/ceog1982.2015
Published: 10 December 2015
Abstract

Objective: Insufficient cytotrophoblast invasion to the myometrium is associated with preeclampsia, especially with the early-onset preeclampsia (before 34 gestational weeks). Several investigations have marked changes in the concentration of cell free fetal DNA in the maternal circulation of women with preeclampsia. However, these studies were not performed for early or late preeclampsia subgroups individually. The present authors planned to determine the levels of the cell free both fetal and maternal DNA in the maternal circulation in early preeclampsia subgroup and compare it with normotensive control cohort. Materials and Methods: A total of 16 women; eight of these with preeclampsia and eight normotensive control cohorts with singleton male pregnancy between 28 and 32 gestational weeks were included in the study. Real-time PCR analysis was performed for determining the circulating cell free DNA levels. Results: Cell free fetal DNA concentrations were higher in early preeclamptic women than control subjects. The authors found no statistically significant difference in each levels of maternal and total DNA between hypertensive and normotensive groups. Conclusions: The present findings suggest that the levels of cell free fetal DNA in maternal circulation were higher in pregnancies which are complicated with early preeclampsia than normotensive controls.
Keywords
Fetal DNA
Maternal DNA
Early-onset preeclampsia
Real-time PCR
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