Purpose: To determine if treatment with dextroamphetamine sulfate can reduce pelvic pain that was attributed to adenomyosis. Materials and Methods: Dextroamphetamine sulfate was given to a 32-year-old woman who suffered on a daily basis from severe chronic pelvic pain that was not relieved by laparoscopic removal of endometriosis by oral contraceptive and ibuprofen. The adenomyosis was diagnosed by magnetic resonance imaging. Results: Within three months the pain was completely gone and has remained absent for six months. Conclusions: Dextroamphetamine sulfate relieved pain from adenomyosis similar to its effect on endometriosis.