IMR Press / CEOG / Volume 42 / Issue 5 / DOI: 10.12891/ceog2058.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
The effect of oocyte reserve on pregnancy rates per oocyte harvest in women aged 36-39
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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive, Endocrinology & Infertility, Camden, NJ
2 Cooper Institute for Reproductive Hormonal Disorders, P.C. Marlton, NJ
3 University of Medicine and Dentistry of New Jersey, School Of Osteopathic Medicine, Stratford, NJ
4 Philadelphia College Of Osteopathic Medicine, Department Of Obstetrics And Gynecology, Philadelphia, PA (USA)
Clin. Exp. Obstet. Gynecol. 2015, 42(5), 573–575; https://doi.org/10.12891/ceog2058.2015
Published: 10 October 2015
Abstract

Purpose: To determine the relative effect of diminished oocyte reserve on clinical viable and live delivered pregnancy rates per transfer and live delivery pregnancy rate per oocyte harvest in women aged 36-39. Materials and Methods: A retrospective comparison of pregnancy outcome was performed over a ten-year time period in women with normal oocyte reserve (day 3 serum FSH ≤11 mIU/mL) vs. diminished reserve (day 3 serum FSH ≥12 mIU/mL). Pregnancy rate per oocyte harvest equals the odds of conceiving with fresh or frozen embryos from a given retrieval before proceeding to another oocyte retrieval. Results: The clinical and viable (at end of first trimester) pregnancy rate per transfer was only 20% lower for the group with diminished oocyte reserve, but was 50% lower for the pregnancy rate per oocyte harvest. Conclusions: Mild stimulation for women with diminished oocyte reserve allows a higher percentage of chromosomally normal embryos in women with diminished oocyte reserve, leading to only a 20% lower clinical and viable pregnancy rate per transfer. However, overall, there are less normal total number of normal embryos leading to a pregnancy rate per oocyte harvest only half as good in the group with lower reserve vs. normal.
Keywords
Mildly advanced age
Oocyte reserve
IVF-ET
Oocyte harvest
Mild ovarian hyperstimulation
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