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The effectiveness of misoprostol or dinoprostone in neonatal outcome after labour induction in post-term nulliparas
M. Soilemetzidis1, P. Pinidis2, N. Tsagias2, A. Ammari2, A. Liberis2, V. Liberis2, G. Galazios2, P. Tsikouras2,*
1 General Hospital Kavala, Kavala
2 Democritus University of Thrace, Department of Obstetrics and Gynecology, Alexandroupolis (Greece)
Clin. Exp. Obstet. Gynecol. 2015, 42(5), 649–652; https://doi.org/10.12891/ceog1981.2015
Published: 10 October 2015
Objective: The object of this study was to investigate the efficacy of vaginal administration of misoprostol versus dinoprostone in neonatal outcome. Materials and Methods: The first Group A included 77 pregnant women, who requested pregnancy termination one week after labour term and received vaginally misoprostol 50 μg, while the other 69 pregnant women in Group B were vaginally administrated three mg dinoprostone. According to the authors’ protocol this procedure was repeated after six hours for a maximum of two times. Results: The labour duration was longer in Group B (p = 0.000), while the APGAR score was better in Group A (p = 0.015). In Group A the labour modus was as follows: 86.9% normal vaginal labour, 3.8% vacuum extraction, and 9.3% cesarean section, while in Group B it was 82.83% normal vaginal labour, 3.07% vacuum extraction, and 14.1% cesarean section. Conclusion: Misoprostol has advantages according to neonatal outcome compared to administration of dinoprostone.