IMR Press / CEOG / Volume 42 / Issue 5 / DOI: 10.12891/ceog1975.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
The association between anti-Mullerian hormone and IVF-ICSI outcome in poor responder patients performing long protocol
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1 Acibadem In Vitro Fertilization Center, Kayseri
2 Bozok University School of Medicine, Department of Obstetrics and Gynecology, Yozgat
3 Karadeniz Technical University School of Medicine, Department of Obstetrics and Gynecology, Trabzon
4 Kayseri In Vitro Fertilization Center, Kayseri (Turkey)
Clin. Exp. Obstet. Gynecol. 2015, 42(5), 663–665; https://doi.org/10.12891/ceog1975.2015
Published: 10 October 2015
Abstract

Purpose of investigation: Ovarian reserve reflects the capacity of the ovaries for a successful pregnancy. Anti-Mullerian hormone (AMH) could be a useful marker to predict ovarian reserve and to adjust controlled ovarian stimulation. The aim of this study was to assess the relationship between AMH and intracytoplasmic sperm injection-in vitro fertilization (IVF-ICSI) outcome in poor responder women. Materials and Methods: This study was conducted prospectively for a period of 12 months. Inclusion criteria were FSH value > 15 iu/l or antral follicle number < 4, on the 2nd day of cycle. All patients underwent GnRH agonist stimulation with long protocol. Serum AMH levels were measured in the treatment cycle just before the stimulation. After the treatment, patients who were pregnant formed the study group and patients who were not pregnant formed the control group. Serum AMH level was the main outcome measure. Results: The study and control group consisted of 34 and 70 patients, respectively. No significant difference was found in duration of infertility, antral follicular count, basal E2 and FSH levels. The mean serum AMH level was significantly higher in study group (p = 0.005). The retrieved oocyte number, metaphase 2 oocyte number, and fertilization rate were also significantly higher in the study group. Discussion: Evaluation of serum AMH seems to be a useful marker to predict IVF-ICSI outcome in poor responder patients.
Keywords
IVF-ICSI
Anti-Mullerian hormone
Poor responder
Ovarian reserve
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