IMR Press / CEOG / Volume 42 / Issue 5 / DOI: 10.12891/ceog1948.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
AT1R A1166C polymorphism and risk of pregnancy-induced hypertension: a meta-analysis of case control studies
H.Y. Wang1,†X.Q. He1,†Z.G. Wang1,*M. Fan1H.X. Liu1
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1 Department of Obstetrics and Gynecology, Beijing (China)
These authors contributed equally.
Clin. Exp. Obstet. Gynecol. 2015, 42(5), 634–639; https://doi.org/10.12891/ceog1948.2015
Published: 10 October 2015
Abstract

Purpose: The purpose of this study was to perform a quantitative review of previous case control studies examining the association between AT1RA1166C polymorphism and pregnancy-induced hypertension (PIH). Materials and Methods: Odds ratio (OR) and 95% confidence intervals (CI) were used as measures of effect sizes. Overall effect sizes were derived using a random-effects model or fixed-effects model when appreciated, and stratified by ethnicity. Funnel plots and Egger’s regression asymmetry tests were utilized for publication bias detection. Results: A total of ten articles (including 920 PIH cases and 1408 controls) were included in this meta-analysis. The overall effect sizes (OR = 2.14, 95% CI: 1.54 - 2.98, p < 0.00001) of additive model indicated PIH patients had a significant higher frequency of allele C. Meanwhile, the OR of the dominant model was 2.22 (95% CI: 1.51 - 3.26, p < 0.00001) which signified that PIH patients also had a significant higher frequency of AC+CC genotypes. The subgroup analyses were in line with the overall outcomes except the Caucasians PIH patients had a non-significant CA+CC genotypes (OR = 1.37, 95% CI: 0.95 - 1.98, p > 0.05). The Egger’s test of additive model (p = 0.451) and dominant model (p = 0.623) revealed no statistical significance for publication bias. Conclusion: The meta-analysis suggested that the AT1R A1166C polymorphism was significantly associated with the PIH, especially in Asian subjects.
Keywords
AT1R
A1166C polymorphism
Meta-analysis
Pregnancy-induced hypertension
Previous case control studies
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