IMR Press / CEOG / Volume 42 / Issue 5 / DOI: 10.12891/ceog1896.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Assessment of follicular and serum VEGF and IGF-1 in ICSI patients: hMG vs rFSH
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1 Dr. Faruk Sukan Women and Children Hospital, Konya
2 Department of Obstetrics and Gynecology, Zubeyde Hanim Maternity Research Hospital, Ankara
3 Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara
4 HRS Ankara Women Hospital, Ankara (Turkey)
Clin. Exp. Obstet. Gynecol. 2015, 42(5), 576–579; https://doi.org/10.12891/ceog1896.2015
Published: 10 October 2015
Abstract

Purpose: To investigate the effect of recombinant follicular stimulating hormone (r-FSH) and human menopausal gonadotropin (hMG) on follicular microenvironment via assessment of follicular and serum vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) levels in intracytoplasmic sperm injection (ICSI) cycles. Materials and Methods: Designed as a prospective cohort study. Twenty-five patients underwent controlled ovarian hyperstimulation (COH) with r-FSH and 20 patients underwent with hMG. Results: Both groups were comparable regarding the women’s mean age and body mass index (BMI). The amount of VEGF (pg/ml) in serum and follicular fluid in the group I and II were comparable (275 ± 135.3 vs 330.7 ± 190.0; p > 0.05 and 2,081.1 ± 1095.1 vs 1,971.1 ± 975.6; p > 0.05, respectively). The amount of IGF-1 (ng/ml) in serum and follicular fluid in the group I and II were also comparable (225.3 ± 69.3 vs 204.1 ± 56.3, p > 0.05 and 176.1 ± 67.2 vs 185.8 ± 48.7, p > 0.05, respectively). Pregnancy rates were also comparable between groups. Conclusions: The hMG and r-FSH in COH produced comparable follicular microenvironment regarding follicular VEGF and IGF-1.
Keywords
Recombinant FSH
hMG
Follicular fluid
VEGF
IGF-1
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