Objective: To assess the prevalence of menopausal-related symptoms and to evaluate their impact on quality of life (QoL) among a sample of menopausal women from Egypt. Materials and Methods: A cross-sectional hospital-based study conducted at the Gynecology department, Suez Canal University, Ismailia – Egypt. A total 1,214 women aged 40 – 70 years were recruited and studied using an interview questionnaire. The questionnaire contains four main items: socio-demographic data, menstruation status assessment, modified Menopausal Rating Scale (MRS), and World Health Organization Quality of Life (WHOQOL-BREF) questionnaire. Results: Mean age was 48.1 ± 10.3 years, with 26.6% of the studied participants were illiterates. According to menstruation status, 40.9% of the studied women were postmenopausal, 41.4% were premenopausal, while 17.7% were perimenopausal. Most of the studied participants have mild/moderate somatic symptoms. Mild/moderate depressive mode, irritability, and anxiety have been reported in 63%, 58.4%, and 58.2% of women, respectively. Postmenopausal women have significantly higher scores on MRS except for urogenital score that was higher in perimenopausal women. They also had significantly lower QoL score in all subscales of WHOQOL-BREF except for psychological domain that was lowest among perimenopausal women. MRS total score has significant negative correlation to all domains of WHOQOL questionnaire. Conclusion: Postmenopausal women have higher prevalence of menopausal symptoms that significantly affect their quality of life more than pre- and perimenopausal women. Those in the transition period (perimenopausal) have higher prevalence of psychological symptoms with higher impact on their psychological welfare.