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Original Research
Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis
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1
Department of Obstetrics and Gynecology, Tangshan Worker’s Hospital, Tangshan Hebei
2
Department of Histology and Embryology, Basic Medical College of Hebei United University, Tangshan Hebei
3
Department of Radiotherapy and Chemotherapy, Tangshan Worker’s Hospital, Tangshan Hebei (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(2), 168–172;
https://doi.org/10.12891/ceog1747.2015
Published: 10 April 2015
Abstract
Aim: This study aims to explore the relationship between COX-2 gene polymorphism and the hereditary susceptibility of endometriosisand adenomyosis. Materials and Methods: Gene polymorphism in COX-2 gene was genotyped in 170 cases of endometriosis, 150 cases of adenomyosis, and 240 matched non-endometriosis and non-adenomyosis controls. Results: Genotypic frequencies of GG, AG, and AA in COX-2 locus in endometriosis and adenomyosis were 16.5%, 51.2%, 32.4% and 16.0%, 49.3%, 34.7%, respectively. They were bothsignificantly different from those in the control group (24.6%, 53.3%, and 22.1%) (p < 0.05). An allele frequency in endometriosis andadenomyosis were significantly higher than that in the control group. The risk of endometriosis or adenomyosis for those carrying two Aalleles were 2.19 and 2.41 times to non-A genotype. Conclusion: Genetic variation of G to A at -1195 locus in the promoter region of COX-2 gene increases the risk of endometriosis and adenomyosis, and the genetic susceptibility of these two diseases are similar.
Keywords
Endometriosis
Adenomyosis
COX-2
genetic susceptibility
Single nucleotide polymorphisms (SNPs)