IMR Press / CEOG / Volume 42 / Issue 1 / DOI: 10.12891/ceog1789.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Changes and clinical significance of peripheral blood helper T lymphocyte and natural killer (NK) cells in unexplained recurrent spontaneous abortion (URSA) patients after abortion and successful pregnancy
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1 Department of Obstetrics and Gynecology, the 2nd Affiliated Hospital of Soochow University, Suzhou
2 Department of Clinical Laboratory, the 2nd Affiliated Hospital of Soochow University, Suzhou (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(1), 62–66; https://doi.org/10.12891/ceog1789.2015
Published: 10 February 2015
Abstract
Objective: This study aims to investigate the number changes and the clinical significance of the peripheral blood T lymphocyte subsets and NK (natural killer) cells in unexplained recurrent spontaneous abortion (URSA) patients before and after abortion, as well as after successful pregnancy. Materials and Methods: Thirty-nine URSA patients (URSA-abortion group), among who 22 patients were followed up until the final successful parturition (URSA-pregnancy group), 31 normal-pregnancy (NP) cases and 25 normal non-pregnancy (NNP) control cases in which the peripheral blood T lymphocytes and subsets, B cells, and NK cells were assessed flow cytometry. Results: Compared with the URSA-pregnancy group and the NP group, the Th cells and NK cells of the URSA-abortion group increased (p < 0.05); compared with the NNP group, the total number of T cells decreased after the first, second, and third month of the URSA abortion (p < 0.05); Th cells decreased within one to six months of the URSA abortion (p < 0.05); proportion of NK cells was significantly higher in URSA patients (p < 0.05). Conclusion: The abnormal numbers of the peripheral blood T cell subsets and NK cells were related with the occurrence of URSA.
Keywords
Recurrent spontaneous abortion
Pregnancy
Helper T lymphocyte
NK cells
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