IMR Press / CEOG / Volume 42 / Issue 1 / DOI: 10.12891/ceog1773.2015

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Case Report
Successful management of discordant alobar holoprosencephaly in monochorionic diamniotic twins with normal karyotype: a case report
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1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu
2 Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(1), 114–116; https://doi.org/10.12891/ceog1773.2015
Published: 10 February 2015
Abstract
Holoprosencephaly (HPE), a complex brain malformation resulting from incomplete cleavage of the prosencephalon into distinct cerebral hemispheres, is rare in newborns. Two preterm male neonates were born at 34 weeks’ and five days’ gestation in the monochorionic diamniotic twin pregnancy complicated with pre-eclampsia and intrahepatic cholestasis of pregnancy, and one of them was prenatally diagnosed with alobar HPE by ultrasonography with frontal bossing, hydrocephaly, hypotelorism of eyes, flat nasal bridge, macroglossia, and cheilo/palatoschisis at birth. Karyotyping by G-banding of amniocentesis specimens in normal twin and fetal umbilical blood in both fetuses showed 46, XY. This report expands discordant alobar holoprosencephaly in monochorionic diamniotic twins.
Keywords
Holoprosencephaly
Monochorionic diamniotic twins
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