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Cite this article
Successful management of discordant alobar holoprosencephaly in monochorionic diamniotic twins with normal karyotype: a case report
1 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu
2 Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, (China)
Clin. Exp. Obstet. Gynecol. 2015, 42(1), 114–116; https://doi.org/10.12891/ceog1773.2015
Published: 10 February 2015
Holoprosencephaly (HPE), a complex brain malformation resulting from incomplete cleavage of the prosencephalon into distinct cerebral hemispheres, is rare in newborns. Two preterm male neonates were born at 34 weeks’ and five days’ gestation in the monochorionic diamniotic twin pregnancy complicated with pre-eclampsia and intrahepatic cholestasis of pregnancy, and one of them was prenatally diagnosed with alobar HPE by ultrasonography with frontal bossing, hydrocephaly, hypotelorism of eyes, flat nasal bridge, macroglossia, and cheilo/palatoschisis at birth. Karyotyping by G-banding of amniocentesis specimens in normal twin and fetal umbilical blood in both fetuses showed 46, XY. This report expands discordant alobar holoprosencephaly in monochorionic diamniotic twins.
Monochorionic diamniotic twins