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Original Research
Fetal nasal bone length at 11+0- 13+6 weeks of gestation: an evaluation of 554 consecutive cases
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1
Department of Radiology, Karadeniz Technical University Faculty of Medicine, Trabzon
2
Department of Obstetrics and Gynecology, Karadeniz Technical University Faculty of Medicine, Trabzon
3
Clinic of Obstetrics and Gynecology, Trabzon Women and Children Hospital, Trabzon (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(5), 556–560;
https://doi.org/10.12891/ceog17692014
Published: 10 October 2014
Abstract
Purpose of investigation: To develop a nomogram for estimating nasal bone length (NBL) at 11+0- 13+6 weeks of gestation in 554 consecutive cases and to determine the value of NBL measurement in screening for chromosomal abnormalities. Materials and Methods: NBL and crown-rump length (CRL) were examined in 554 fetuses at 11+0-13+6 weeks’ gestation. A nomogram for NBL was developed with data from 479 healthy fetuses in which fetal profile examination was possible. Reference values, including percentiles, were calculated for each gestational age. Result: A linear correlation was noted between CRL and NBL in healthy fetuses at 11+0-11+6, 12+0-12+6 and 13+0-13+6 weeks of gestation. Mean NBL was 2.18 ± 0.53 mm, 2.46 ± 0.45 mm, and 2.91 ± 0.55 mm in healthy fetuses, for these time frames, respectively. NBL increased significantly with CRL from respective means of 2.26 ± 0.43, 2.60 ± 0.48, 2.77 ± 0.43, and 3.16 ± 0.52 mm at 45 - 54.9, 55 - 64.9, 65 - 74.9, and 75 - 84 mm. Conclusion: The authors developed a NBL nomogram with data from normal, healthy Turkish fetuses at 11+0-13+6 weeks of gestation. These reference ranges may prove useful in prenatal screening and diagnosis of syndromes known to be associated with nasal hypoplasia.
Keywords
Fetal nasal bone
Ultrasonography
Chromosomal abnormalities