IMR Press / CEOG / Volume 41 / Issue 5 / DOI: 10.12891/ceog17372014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Normal “high” thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs
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1 University Center of Reproductive Medicine, Hospital Universitario of the Universidad Autonoma de Nuevo Leon in Monterrey, Monterrey (Mexico)
2 Servicio de Ginecología Hospital Vall d`Hebron, Universitat Autonoma de Barcelona in Barcelona (Spain)
Clin. Exp. Obstet. Gynecol. 2014, 41(5), 517–520; https://doi.org/10.12891/ceog17372014
Published: 10 October 2014
Abstract

Objective: To determine if a relationship exists between pregnancy rates obtained in patients undergoing in vitro fertilization (IVF) with donor eggs and levels of thyroid stimulating hormone greater than 2.5 mIU/L but still within a range considered normal. Study design: Retrospective comparative cohort study. With prior approval of the Ethics Committee, 233 patients undergoing IVF with donor eggs, in a two-year period, were included. Patients were grouped depending on the thyroid stimulating hormone (TSH) level. Pregnancy rates were compared. Statistical analysis was made with the Chi-square test. Results: Pregnancy rates, depending on the TSH level, were 56.6% in patients with TSH levels below 2.49 mU/L vs. 21.6%, in patients with levels above 2.5 mU/L. This difference was statistically significant (p < 0.001). Conclusions: Mild abnormalities of thyroid function may adversely affect the pregnancy rates in patients undergoing in vitro fertilization with donor eggs. A possible alteration in endometrial function may be associated.
Keywords
Thyroid stimulating hormone
In vitro fertilization (IVF)
Egg donation
Clinical pregnancy rates
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