IMR Press / CEOG / Volume 41 / Issue 2 / DOI: 10.12891/ceog16142014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
The association between inherited thrombophilia and recurrent pregnancy loss in Turkish women
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1 Nenehatun Obstetrics and Gynecology Hospital, Erzurum
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Erzincan University, Erzincan
3 Department of Obstetrics and Gynecology, Faculty of Medicine, Ataturk University, Erzurum
4 Department of Medical Biology, Faculty of Medicine, Ataturk University, Erzurum
5 Department of Medical Genetic, Faculty of Medicine, Ataturk University, Erzurum (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(2), 177–181; https://doi.org/10.12891/ceog16142014
Published: 10 April 2014
Abstract

Objective: To investigate the relation between recurrent pregnancy loss (RPL) and factor V Leiden, prothrombin G20210A, and C677T methylenetetrahydrofolate reductase (MTHFR) mutations. Materials and Methods: A case-control study was conducted on 95 consecutive cases with RPL, and 40 age-matched controls who had no history of pregnancy loss and had at least one successful pregnancy. After application of exclusion criteria, 60 patients in the study group and 40 control cases were compared for thrombophilic factors. Results: Thirteen out of 60 RPL cases and one out of 40 in the control group were carriers of factor V Leiden mutation. While six patients were carriers of prothrombin G20210A gene mutation, none in the control group carried this mutation. Twenty-nine out of 60 RPL cases and 17 out of 40 control cases had MTHFR mutation. Conclusion: The authors found a positive correlation between RPL and FVL and FII gene mutations, but no significant association between RPL and MTHFR gene mutation.
Keywords
Recurrent pregnancy loss
Factor V Leiden
Prothrombin G20210A mutation
MTHFR C677T mutation
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