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Original Research
Alteration of T-cell subpopulations and lipid peroxidation in the blood of patients with vulvar non-neoplastic epithelial disorder
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1
Department of Obstetrics and Gynecolgy, China Meitan General Hospital, Chaoyang District, Beijing
2
Department of Pathology, Capital Medical University, You An Men, Beijing (China)
Clin. Exp. Obstet. Gynecol. 2014, 41(2), 174–176;
https://doi.org/10.12891/ceog16132014
Published: 10 April 2014
Abstract
Objective: To determine the relationship between vulvar non-neoplastic epithelial disorder and thymus-dependent lymphyocyte levels and lipid peroxidation. Materials and Methods: the authors measured the levels of CD3+, CD4+, CD8+, CD16+ T cell, and the concentration of superoxide dismutase (SOD) and malondialdehyde (MDA) in the blood of 62 patients with vulvar non-neoplastic epithelial disorder. A control group consisted of 30 normal women from the present hospitals. Results: The level of CD4+/CD8+ T-lymphocytes and SOD in the blood of the patients with vulvar non-neoplastic epithelial disorder was significantly lower than that in control subjects, but the level of MDA was higher as compared with normal women. Conclusion: There is increased immune activation and lipid peroxidation in patients with vulvar non-neoplastic epithelial disorder, which could contribute to destruction of vulvar tissue.
Keywords
Vulvar non-neoplastic epithelial disorder
Thymus-dependent lymphyocyte
Lipid peroxidation
Superoxide dismutase