IMR Press / CEOG / Volume 41 / Issue 2 / DOI: 10.12891/ceog15802014

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Implications of premature ovarian failure on bone turnover markers and bone mineral density
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1 Department of Obstetrics and Gynecology
2 Department of Biochemistry, Istanbul University School of Medicine, Istanbul (Turkey)
Clin. Exp. Obstet. Gynecol. 2014, 41(2), 149–153;
Published: 10 April 2014

Introduction: Premature ovarian failure (POF) is the cessation of ovarian function before the age of 40. The loss of ovarian function, whether premature or not, has an overwhelming impact on female skeletal health, leading to an increased risk of developing osteoporosis because of the lengthened time of exposure to reduced estrogen. The objective of this study was to compare the implications of premature ovarian failure on bone turnover markers and bone mineral density in patients under the age of 40. Materials and Methods: Sixty-one patients with a diagnosis of POF were selected for this prospective study. Patients were divided into two groups according to age, patients < 30 years old (n = 30), and patients ≥ 30 years old (n = 31). Results: Between the two age sub-groups (< 30 and ≥ 30 years old), there was a significant difference in menopause rating scale (MRS), lumbar spine t-score, N-telopeptides crosslinks (NTx), and serum bone specific alkaline phosphatase (bALP) between the two age groups (10.93 ± 7.79 vs 17.38 ± 8.62; -1.84 ± 1.47 vs -1.06 ± 0.93; 58.80 ± 21.32 vs 41.1 ± 11.37; 48.99 ± 42.16 vs 23.76 ± 10.08, respectively). Conclusion: It is apparent that bone mineral density (BMD) is commonly less in women with POF than normal healthy women. Therefore, measurement of BMD is warranted. At this time, it is not clear how often the tests should be carried out to evaluate BMD. Further prospective studies are required to establish guidelines. However, it seems reasonable to monitor women with POF yearly for the presence of any endocrine dysfunction and to assess BMD at periodic intervals.
Premature ovarian failure
Bone mineral density
Bone turnover markers
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