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Original Research
Biomarkers of peritoneal fluid in endometriosis identified by surface-enhanced laser desorption/ionization time-of-flight
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1
The 2nd Affiliated Hospital, Department of Gynecology, and Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou
2
The 2nd Affiliated Hospital, Cancer institute, and Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou (China)
Clin. Exp. Obstet. Gynecol. 2014, 41(1), 72–74;
https://doi.org/10.12891/ceog16342014
Published: 10 February 2014
Abstract
Objectives: This work aims to detect the peritoneal fluid proteomic patterns in endometriosis patients, build diagnostic models, and evaluate its clinical significance. Study Design: The authors used SELDI-TOF-MS protein chip array technology to detect biomarkers of peritoneal fluid in endometriosis patients. Fourteen endometriosis patients and 16 persons without endometriosis as control group were tested. Results: Four potential biomarkers (4428m/z, 6891m/z, 13766m/z, and 6427m/z) were found. Conclusions: This method showed great potential in screening better biomarkers for endometriosis.
Keywords
Endometriosis
Peritoneal fluid
Surface-enhanced laser desorption/ionization time-of-flight
Biomarkers
adenomyosis