IMR Press / CEOG / Volume 40 / Issue 4 / pii/1630389123805-760603323

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Role of environmental organochlorinated pollutants in the development of endometriosis
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1 Department of Obstetrics-Gynecology and Urology, “Sapienza” University of Rome, Rome (Italy)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 565–567;
Published: 10 December 2013
Abstract

Endometriosis is a gynecological disease, which involves the growth of endometrial tissue outside the uterine cavity, commonly in the pelvic region. The etiology of the disease is unclear, but multiple factors may contribute to its pathogenesis. Environmental organochlorinated pollutants, particularly dioxins and polychlorinated biphenyls (PCBs), are thought to play a role in the development of this disease; however, the results of clinical trials are discordant, and it is not clear how the effect of exposure to these compounds is linked to endometriosis. Their effects on cytokines, immune system, hormones, and growth factors are thought to increase the risk of endometriosis. The purpose of this review is to provide an overview of epidemiological studies, which have evaluated the relationship between endometriosis and exposure to persistent organochlorinated pollutants.
Keywords
Endometriosis
TCDD
PCB
Persistent organic pollutants
Organochlorinated pesticides
Dioxin-like compounds
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