IMR Press / CEOG / Volume 40 / Issue 4 / pii/1630389113526-2139915220

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Expression of regulatory T and helper T cells in peripheral blood of patients with pregnancy-induced hypertension
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1 Department of Obstetrics, The Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Provence (China)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 502–504;
Published: 10 December 2013
Abstract

Objective: To analyze the expression of regulatory T cells and helper T cells in peripheral blood of patients with pregnancy-induced hypertension (PIH). Materials and Methods: Twenty-seven patients hospitalized with PIH were consecutively collected for detection of regulatory T cells (CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg) and helper T (CD+3, CD+4, CD+8, CD+4/CD+8) cells in peripheral blood. Meanwhile, 20 normal hospitalized pregnant women served as the control group. Results: In the comparison of regulatory T cells, the level of serum CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg in PIH group was significantly lower than control group (all p < 0.05). In the comparison of help T cells, the expression level of serum CD+4/CD+8 in PIH group was obviously higher than control group, while the expression level of CD+8 was significantly lower than control group (all p < 0.05). Conclusions: There were obvious abnormal expressions of regulatory T cell and helper T cells in peripheral blood of patients with PIH.
Keywords
Pregnancy-induced hypertension
Regulatory T cells/peripheral blood
Helper T cells/peripheral blood
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