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Original Research
Expression of regulatory T and helper T cells in peripheral blood of patients with pregnancy-induced hypertension
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1
Department of Obstetrics, The Fourth Affiliated Hospital of China Medical University, Shenyang City, Liaoning Provence (China)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 502–504;
Published: 10 December 2013
Abstract
Objective: To analyze the expression of regulatory T cells and helper T cells in peripheral blood of patients with pregnancy-induced hypertension (PIH). Materials and Methods: Twenty-seven patients hospitalized with PIH were consecutively collected for detection of regulatory T cells (CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg) and helper T (CD+3, CD+4, CD+8, CD+4/CD+8) cells in peripheral blood. Meanwhile, 20 normal hospitalized pregnant women served as the control group. Results: In the comparison of regulatory T cells, the level of serum CD4+ CD25+ Treg and CD4+ CD25+ Foxp3+Treg in PIH group was significantly lower than control group (all p < 0.05). In the comparison of help T cells, the expression level of serum CD+4/CD+8 in PIH group was obviously higher than control group, while the expression level of CD+8 was significantly lower than control group (all p < 0.05). Conclusions: There were obvious abnormal expressions of regulatory T cell and helper T cells in peripheral blood of patients with PIH.
Keywords
Pregnancy-induced hypertension
Regulatory T cells/peripheral blood
Helper T cells/peripheral blood