IMR Press / CEOG / Volume 40 / Issue 4 / pii/1630389108800-169911061

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Secondary amenorrhea despite normal endometrial development with secretory changes and absence of uterine synechiae – a second case of the endometrial compaction – apoptosis syndrome
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1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ
2 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
3 Philadelphia College of Osteopathic Medicine, Department of Obstetrics and Gynecology, Philadelphia, PA (USA)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 473–474;
Published: 10 December 2013

Purpose: To report the second case of amenorrhea related to endometrial compaction apoptosis syndrome. Materials and Methods: A female with secondary amenorrhea was evaluated with sonography, hysteroscopy, serum estradiol and progesterone levels, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and endometrial biopsy. Results: Initially she was found to be ovulatory. However she did not menstruate despite the development of adequate endometrial thickness and a normal secretory endometrial biopsy. Hysterosalpingogram failed to detect synechial. Subsequently she developed hypogonadotropic hypogonadism, but she still failed to menstruate despite estrogen followed by progesterone. Conclusions: Amenorrhea can occur despite secretory endometrial changes without a uterine abnormality.
Normal uterine cavity
Endometrial compaction
Endometrial apoptosis
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