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Cite this article
Secondary amenorrhea despite normal endometrial development with secretory changes and absence of uterine synechiae – a second case of the endometrial compaction – apoptosis syndrome
1 The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ
2 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
3 Philadelphia College of Osteopathic Medicine, Department of Obstetrics and Gynecology, Philadelphia, PA (USA)
Clin. Exp. Obstet. Gynecol. 2013, 40(4), 473–474;
Published: 10 December 2013
Purpose: To report the second case of amenorrhea related to endometrial compaction apoptosis syndrome. Materials and Methods: A female with secondary amenorrhea was evaluated with sonography, hysteroscopy, serum estradiol and progesterone levels, serum luteinizing hormone (LH), follicle stimulating hormone (FSH), and endometrial biopsy. Results: Initially she was found to be ovulatory. However she did not menstruate despite the development of adequate endometrial thickness and a normal secretory endometrial biopsy. Hysterosalpingogram failed to detect synechial. Subsequently she developed hypogonadotropic hypogonadism, but she still failed to menstruate despite estrogen followed by progesterone. Conclusions: Amenorrhea can occur despite secretory endometrial changes without a uterine abnormality.
Normal uterine cavity