Purpose: To present a novel approach to prevent miscarriage by treatment with sympathomimetic amines. Materials and Methods: Two women undergoing in vitro fertilization-embryo transfer (IVF-ET) with a history of recurrent miscarriage even in IVF-ET cycles were treated with dextroamphetamine sulfate prior to their next IVF-ET cycles. Results: Both women successfully completed their first trimester. One woman delivered a live baby and one had neonatal death related to prematurity secondary to severe pre-eclampsia. Conclusions: Sympathomimetic amines therapy may prove to be an effective therapy to prevent recurrent miscarriage especially in women who have failed despite progesterone therapy, and where no other etiologic factors have been determined.