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Original Research
Effect of poor motility on pregnancy outcome following intracytoplasmic sperm injection in couples whose male partners have subnormal hypo-osmotic swelling test scores
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1
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ
2
Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2013, 40(3), 315–316;
Published: 10 September 2013
Abstract
Purpose: To determine the confounding effect, if any, of poor motility of sperm that are already compromised by an abnormal hypo-osmotic swelling (HOS) test on pregnancy outcome following in vitro fertilization-embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI). Materials and Methods: Clinical and live-delivered pregnancy and implantation rates were retrospectively evaluated in first cycles of couples undergoing IVF-ET with ICSI where the HOS test was < 50% according to deciles of subnormal percentage motility (< 50%) and compared to those with normal motility ≥ 50%. Results: The combination of very poor motility and low HOS test scores did diminish pregnancy rates following IVF with ICSI. Conclusions: The only part of fertilization of the oocyte that ICSI does not overcome is phase 2 of oocyte activation. Based on these data, the combination of very low percentage motility and low HOS test scores do not adversely affect pregnancy outcome following IVF with ICSI.
Keywords
Hypo-osmotic swelling test
Intracytoplasmic sperm injection
Motility
In vitro fertilization-embryo transfer