IMR Press / CEOG / Volume 40 / Issue 2 / pii/1630388173104-251339570

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Defective oocytes are not a common cause of unexplained infertility as determined by evaluation of sharing oocytes between infertile donors and recipients
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1 Temple University School of Medicine, Department of Medicine, Philadelphia, PA
2 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2013, 40(2), 193–195;
Published: 10 June 2013
Abstract

Purpose: To determine if defective oocytes or sperm may be a common etiologic factor in unexplained infertility. Materials and Methods: A retrospective comparison of fertilization rates and pregnancy rates from infertile donors with unexplained infertility trying to conceive with in vitro fertilization-embryo transfer (IVF-ET) and their respective recipients, who shared the other half of the oocytes with the recipient’s male partner for financial compensation was performed. Pregnancy rates from donors and recipients were also compared to other donor recipient pairs sharing oocytes from infertile donors with tubal or male factor or financiallycompensated donors providing oocytes to two recipients. Results: Pregnancy rates from infertile donors with unexplained infertility were comparable not only to their respective recipients but to other donor/recipient pairs that received oocytes from donors with tubal or male factor or financially-compensated donors. Fertilization rates were somewhat reduced in the infertile donors. Conclusions: Abnormal embryos resulting from an oocyte or sperm defect do not appear to be a common cause of unexplained infertility. The possibility does exist that sperm may be an etiologic factor in reduced fertilization potential, which not only could be obviated by conventional oocyte insemination, but could be further improved by intracytoplasmic sperm injection (ICSI).
Keywords
Oocyte sharing
Infertile donors
Oocyte recipients
Fertilization rates
Pregnancy rates
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