IMR Press / CEOG / Volume 40 / Issue 1 / pii/1630388040267-1778281019

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Origianal Research
Ondansetrone or metoclopromide? Which is more effective in severe nausea and vomiting of pregnancy? A randomized trial double-blind study
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1 Department of Internal Medicine, Babol University of Medical Science, Babol
5 Pharmacology and Physiology Department, Babol University of Medical Science, Babol (Iran)
234 Fatemezahra Infertility and Reproductive Health Research Center, Babol University of Medical Science, Babol
Clin. Exp. Obstet. Gynecol. 2013, 40(1), 127–130;
Published: 10 March 2013
Abstract

Background: Nausea and vomiting of pregnancy (NVP) are seen in 50-80% of pregnancies. However, in severe NVP, called hyperemesis gravidarum (HG), medical therapy to reduce nausea and vomiting is inevitable and ondansetron (OND) as an effective drug has recently been proposed. This study evaluated the effectiveness of OND versus metoclopramide (MET) in the treatment of HG. Methods: In this clinical trial study, 83 pregnant women with HG were enrolled in 2011-2012 and randomly divided in two groups. The first group received oral administration of MET and the second group was treated with OND for two weeks. Severity of nausea and vomiting were evaluated according to visual analogue scale (VAS) criteria. Data analysis was done by χ2, Fisher exact test and Student’s t-test. Results: Comparison of the trend of change of vomiting in the two groups during the 14-day treatment showed the OND group had significantly lower vomiting scores versus the MET group (p = 0.042), while there was no significant difference in the trend of nausea. Conclusion: OND has a more favorable effect in controlling severe vomiting.
Keywords
Methoclopramide
Ondansetron
Nausea
Vomiting
Pregnancy
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