IMR Press / CEOG / Volume 40 / Issue 1 / pii/1630388023750-710354478

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Origianal Research
Placental apoptosis in preeclampsia, intrauterine growth retardation, and HELLP syndrome: An immunohistochemical study with caspase-3 and bcl-2
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1 Department of Obstetrics and Gynecology, Ataturk Education and Research Hospital, Ankara
2 Department of Obstetrics and Gynecology, Kecioren Education and Research Hospital, Ankara
3 Department of Pathology, Dr. Zekai Tahir Burak Woman Health Education and Research Hospital, Ankara
4 Department of Obstetrics and Gynecology, Dr. Zekai Tahir Burak Woman Health Education and Research Hospital, Ankara (Turkey)
Clin. Exp. Obstet. Gynecol. 2013, 40(1), 45–48;
Published: 10 March 2013
Abstract

Objective: To examine the placental expression of caspase-3 and bcl-2 in pregnancies complicated by preeclampsia, IUGR, and HELLP syndrome. Materials and Methods: A prospective case-control study was conducted on 50 pregnant women between December 2006 and August 2007 at Dr. Zekai Tahir Burak Women Health Research and Education Hospital, Ankara, Turkey. Placental tissue samples were obtained from 15 pregnancies complicated by preeclampsia, 15 pregnancies with normotensive IUGR, five pregnancies with HELLP syndrome, and 15 gestational age-matched normotensive pregnancies without intrauterine infection as a control group. The placental expression of caspase-3 and bcl-2 has been investigated by immunohistochemical staining. Results: Caspase-3 immunostaining score was significantly higher in each group when compared with the control group (p = 0.002). However there was no statistically signifant difference with bcl-2 immunostaining in each group when compared with the control group. Conclusions: Apoptotic marker caspase-3 is significantly increased in the villous trophoblasts of patients with preeclampsia, HELLP syndrome, and IUGR indicating increased placental apoptosis.
Keywords
Caspase-3
Bcl-2
Apoptosis
Preeclampsia
IUGR
HELLP syndrome
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