IMR Press / CEOG / Volume 40 / Issue 1 / pii/1630388019758-997494207

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Origianal Research
The effect of diminished oocyte reserve in younger women (age ≤ 37) on pregnancy rates in natural cycles
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1 Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Camden, NJ (USA)
Clin. Exp. Obstet. Gynecol. 2013, 40(1), 27–28;
Published: 10 March 2013

Purpose: To determine the relative confounding effect of diminished oocyte reserve on the chance of successful pregnancy in nonin vitro fertilization-embryo transfer (IVF-ET) cycles. Materials and Methods: Matched controlled study comparing pregnancy outcome in women aged ≤ 37 years with severely decreased oocyte reserve as manifested by a day 3 serum follicle stimulating hormone (FSH) ≥ 15 mIU/ml compared to women with normal oocyte reserve (serum FSH ≤ 8 mIU/ml). Couples were excluded if they did not have tubal patency or a semen analysis that required IVF-ET. Only couples that tried at least three natural cycles (unless pregnancy occurred first) were included. Results: The live delivered pregnancy rates within a maximum of five cycles of luteal phase support with progesterone (P) or at most mild FSH stimulation, or intrauterine insemination for mild male factor or cervical factor was 33.3% (8/24) with increased day 3 FSH and 62.5% (16/24) for the normal group (p = 0.08, Fisher’s exact test). Conclusion: Women with marked oocyte depletion are half as likely to conceive with assisted reproductive techniques compared to women with normal oocyte reserve.
Natural cycles
Diminished oocyte reserve
Live delivered pregnancy rates
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