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Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Case Report
Holoprosencephaly in clomiphene-induced pregnancy: a possible association? A case report and literature review
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1
Poison Control Centre and Teratology Information Service, Ospedali Riuniti, Bergamo
2
Poison Control Centre, IRCCS Fondazione Maugeri and University of Pavia (Italy)
Clin. Exp. Obstet. Gynecol. 2012, 39(4), 535–536;
Published: 10 December 2012
Abstract
Clomiphene is widely used for inducing ovulation. Evidence for congenital abnormalities, in particular central nervous system defects (CNS-D) and in babies born from clomiphene-induced pregnancies is conflicting. The authors report a case of holoprosencephalia (HPE) in a fetus delivered from a mother receiving clomiphene.
Keywords
Pregnancy
Malformation
Clomiphene
Holoprosencephaly