IMR Press / CEOG / Volume 39 / Issue 4 / pii/1630475830058-2009212351

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Determining the optimal fentanyl dose for dilation and curettage procedures
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1 Department of Anesthesiology and Reanimation, Adnan Menderes University, Faculty of Medicine, Aydın
2 Aydin Maternity and Childcare Hospital, Aydin (Turkey)
Clin. Exp. Obstet. Gynecol. 2012, 39(4), 509–511;
Published: 10 December 2012
Abstract

Aim: This study attempted to determine an optimal dose of fentanyl, a drug frequently used in dilation and curettage (D&C) procedures, which is commonly performed as a brief outpatient intervention. Methods: The optimal fentanyl dose was determined using Dixon’s up-and-down method. The study was accomplished with a beginning fentanyl dose of 1 μg kg-1 with a step size of 0.1 μg kg-1 fentanyl. Results: The ED50 [95% confidence interval (CI)] for fentanyl for successful anesthesia in D&C procedures was found to be 0.45 (0.35-0.55) μg kg-1 and the ED95 value was 0.50 (0.45-0.60) μg kg-1. Conclusion: This dose is considerably lower than the standard dose that is used at present, which is 1 μg kg-1. To the best of our knowledge, the current study is the first to show that a significantly reduced dose of fentanyl can be as effective as higher doses in D&C procedures using Dixon’s up-and-down method.
Keywords
Fentanyl
Dilation and curettage
Optimal dose
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