IMR Press / CEOG / Volume 39 / Issue 4 / pii/1630475822851-19119270

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish population and risk for preeclampsia
Show Less
1 Department of Obstetrics and Gynecology, Uludag University, Bursa
2 Department of Medical Genetics, Uludag University, Bursa
3 Bursa ART Center, Bursa (Turkey)
Clin. Exp. Obstet. Gynecol. 2012, 39(4), 466–469;
Published: 10 December 2012
Abstract

Aims: This study was conducted to investigate whether insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene and polymorphisms in glutathione S-transferase (GST) M1 and T1 genes are associated with increased risk for preeclampsia. Materials and Methods: Sixty-three patients with hypertensive disorder of pregnancy and 85 controls were evaluated in a prospective case-control study. All subjects were genotyped by polymerase chain reaction (PCR) followed by agarose gel electrophoresis. Results: Allele frequencies of ACE gene I/D polymorphism were found significantly different between preeclampsia and the control groups (p = 0.001). Differences in genotype frequencies of ACE gene I/D polymorphism between the two groups were statistically significant (p = 0.004). Individuals homozygous for D allele were more likely to develop preeclampsia (OR = 2.29; 95% CI, 1.39 - 3.79), whereas heterozygous individuals were not at increased risk (OR = 0.92; 95% CI, 0.56 - 1.49), compared to individuals homozygous for I allele. The differences in frequencies of functional and null alleles of GSTM1 and GSTT1 genes between the two groups were not significant (p = 0.46 and p = 0.44, respectively). Conclusion: ACE gene DD genotype was found to be associated with increased risk of preeclampsia development, whereas the authors did not find any significant relationship with polymorphisms of the GSTM1 and GSTT1 genes and preeclampsia.
Keywords
Gene
Polymorphism
Angiotensin-converting enzyme
Glutathione s-transferase
Preeclampsia
Share
Back to top