IMR Press / CEOG / Volume 39 / Issue 3 / pii/1630480838621-465391181

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
The efficacy of dinoprostone vaginal insert for active management of premature rupture of membranes at term: a randomized controlled trial
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1 Izmir Ataturk Training and Research Hospital, 1st Department of Gynecology and Obstetrics, Izmir (Turkey)
Clin. Exp. Obstet. Gynecol. 2012, 39(3), 356–358;
Published: 10 September 2012
Abstract

Purpose: To evaluate the efficacy and safety of the vaginal insertion of dinoprostone in terms of achieving cervical ripening, shortening the length of labor, and lowering the cesarean delivery rate for term pregnancies complicated with premature rupture of membranes. Methods: A prospective, randomized, controlled trial enrolled 100 women with term pregnancies complicated with premature rupture of membranes. Each had a normal non stress test, unscarred uterus, a singleton pregnancy with cephalic presentation, and a Bishop score of less than 4. Patients were randomized to receive a 10 mg dinoprostone vaginal insert single dose or no medication. After cervical ripening, oxytocin induction was performed during labor for both the study and control group. Cervical ripening in the 12th hour, total delivery time and delivery mode were compared between the two groups. Results: More often cervical ripening was obtained in the study group women who used dinoprostone vaginal inserts compared to the control group (p: 0.001). Latent phase of labor and total delivery time was shorter in the study group women than the control group (p: 0.022 and p: 0.026). There was no difference in terms of delivery mode and indication of section between study and control groups. Conclusion: The use of dinoprostone vaginal inserts in patients with term pregnancy of premature rupture of membranes reduced both the latent phase of labor and total delivery time without increasing the rate of cesarean section.
Keywords
Premature rupture of membranes
Dinoprostone vaginal insert
Cervical ripening
Labor induction
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